Prof. Dr. Wang Decheng
E-mail: dcwang99@163.com; dcwang@fudan.edu.cn
Faculty: Medical College of China Three Gorges University
Job Title: Professor, Chief Physician
1. Education
(1) September 2005-June 2008: China Agricultural University
(2) September 2002-June 2005: Yunnan Agricultural University
2. Professional Experiences
(1) July 2017-now: Medical College of China Three Gorges University
(2) Mar 2015-June 2017: Post-doc research associate, Purdue University
(3) Jan 2014-Feb 2015: Medical College of China Three Gorges University
(4) Mar 2012-July 2013, Visiting Scholar, Tuberculosis Research Section, NIAID, NIH
(5) July 2008-Jan 2014, Faculty of Shanghai Medical College, Fudan University
3. Research Directions
(1) Host-pathogen Interaction and Earlier Biomarker Identification
(2) Persist Infection Mediated by Intracellular Bacteria and Molecular Mechanism
4. Published Papers (since 2011)
(1) Cao Zhou, Dan Li, Cairong Ding, Qiulin Yuan, Shi Yu, Debing Du, Weifeng Huang, Decheng Wang* (corresponding author). Involvement of SIRT1 in amelioration of schistosomiasis-induced hepatic fibrosis by genistein. Acta Trop. 2021, Aug; 220:105961.
(2) Xing Liu, Hongqian Zhao,Chunyan Luo,Debin Du,Jinlong Huang,Quan Ming,F en Jin, Decheng Wang* (corresponding author), Weifeng Huang*. Acetaminophen Responsive miR-19b Modulates SIRT1/Nrf2 Signaling Pathway in Drug-Induced Hepatotoxicity. Toxicol Sci. 2019, 170(2):476-488.
(3) Han S, Lv Y, Wang J, Gao M, Yuan F, Wang D (corresponding author). VPS-22/SNF8 regulates longevity via modulating the activity of DAF-16 in C. elegans. Biochem Biophys Res Commun. 2020 Oct 29;532(1):94-100.
(4) Kan Y, Meng L, Xie L, Liu L, Dong W, Feng J, Yan Y, Zhao C, Peng G, Wang D, Lu M, Yang C, Niu C. Temporal modulation of host aerobic glycolysis determines the outcome of Mycobacterium marinum infection. Fish Shellfish Immunol. 2020 Jan; 96:78-85.
(5) Alan Y. Hsu, Decheng Wang, Sheng Liu, Justice Lu, Ramizah Syahirah, David A. Bennin,Anna Huttenlocher, David M. Umulis, Jun Wan, Qing Deng. Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration. PNAS. 2019 116 (37) 18561-18570.
(6) Alan Yi-Hui Hsu#, Decheng Wang# (Co-first author), Theodore Gurol#, Wenqing Zhou, Xiaoguang Zhu, Hsiu-Yi Lu, Qing Deng.Overexpression of microRNA- 722 fine-tunes neutrophilic inflammation through inhibiting Rac2 in zebrafish. Disease Models & Mechanisms. 2017, 10 (11):1323-1332.
(7) Xinhua Huang, Hui Wang, Lu Meng, Qinglan Wang, Jia Yu, Qian Gao, Decheng Wang* (corresponding author). Role of eosinophils and apoptosis in PDIMs/PGLs deficient mycobacterium elimination in adult zebrafish. Dev Comp Immunol.2016, 59:199-206.
(8) Li M, Du X, Villaruz AE, Diep BA, Wang D, Song Y, Tian Y, Hu J, Yu F, Lu Y, Otto M. MRSA epidemic linked to a quickly spreading colonization and virulence determinant. Nature Medicine. 2012, 18(5):816-9.
(9) Dong D, Wang D, Li M, Wang H, Yu J, Wang C, Liu J, Gao Q. PPE38 modulates the innate immune response and is required for Mycobacterium marinum virulence. Infect Immun. 2012 Jan; 80(1):43-54.
5. Research Projects (since 2011)
(1) Molecular pathogenesis of apoptosis manipulated by PDIM in Tuberculosis. National Natural Science Foundation of China (NSFC), grant No. 31001045.
(2) The molecular mechanism of Sumoylation in mycobacterial lipid PDIM mediates granuloma formation. National Natural Science Foundation of China (NSFC), grant No. 31572485.
(3) The significance and machanism of cytoskeletal protein IQGAP1 in the infection and granuloma formation mediated by mycobacterial PDIM cell wall lipid. National Natural Science Foundation of China (NSFC), grant No. 31772709.
Prof. Zou Lili
E-mail: zoulili@ctgu.edu.cn
Faculty: Medical College of China Three Gorges University
Job Title: Professor
1. Education
(1) September 2008-June 2011: Doctor, Sun-Yat Sen University
(2) September 2005-June 2008: Post-graduate, Southwest University
(3) September 2008-June 2011: Bachelor, Southwest University
2. Professional Experiences
(1) July 2011-now: Lecturer, Associated professor, Professor, China Three Gorges University
(2) May 2015-May 2017: Ph. D., Karolinska Institute
3. Research Directions
(1) Pathogenic Biology and Immunology
(2) Molecular Biology
4. Published Papers (since 2011)
(1) Xin Zuo, Ying Zhao, Jintao Zhao, Yanfang Ouyang, Wenjun Qian, Yinmei Hou, Chong Yu, Xiaoyuan Ren, Lili Zou, Jianguo Fang, Jun Lu*. A fluorescent probe for specifically measuring thioredoxin and glutaredoxin reducing activity in bacterial cells [J]. Analyst. 2022, 147, 834-840.
(2) Qianqian Lu, Yi Cai, Chenyan Xiang, Tao Wu, Ying Zhao, Jun Wang*, Helen Wang*, Lili Zou*. Ebselen, a multi-target compound: its effects on biological processes and disease [J]. Expert Reviews in Molecular Medicine. 2021, e12: 1-11.
(3) Geir Bjørklund*, Lili Zou, Jun Wang, Christos T. Chasapis, Massimiliano Peana*. Thioredoxin reductase as a pharmaceutical target [J]. Pharmacological Research. 2021, 174: 195854-195865.
(4) Yu Liu#, Lili Zou#, Peng Wang, Yanyan Qin, Chunling Yuan, Jingxuan Zhou, Jun Wang*. Construction of differential expression plasmids of NGF for cancer-related neurogenesis study [J]. Experimental and Therapeutic Medicine. 2021, 21: 363-375.
(5) Peng Wang, Jun Wang, ZonglanXie, Jingxuan Zhou, Qianqian Lu, Ying Zhao, Chuanjiang Dong*, Lili Zou*. Depletion of multidrug-resistant uropathogenic Escherichia coli BC1 by ebselen and silver ion [J]. Journal of Cellular and Molecular Medicine. 2020, 24(22): 13139-13150.
(6) Jun Wang#, Peng Wang#, Chuanjiang Dong, Ying Zhao, Jingxuan Zhou, Chunling Yuan, Lili Zou*. Mechanisms of ebselen as a therapeutic and its pharmacology applications [J]. Future Medicinal Chemistry. 2020, 12(23): 2141-2160.
(7) Chuanjiang Dong#, Jun Wang#, Huan Chen, Peng Wang, Jingxuan Zhou, Ying Zhao, Lili Zou*. Synergistic therapeutic efficacy of ebselen and silver ion against multidrug-resistant Acinetobacter baumannii-induced urinary tract infections [J]. Metallomics. 2020, 12, 860-867.
(8) Chuanjiang Dong#, Jingxuan Zhou#, Peng Wang#, Tao Li, Ying Zhao, Xiaoyuan Ren, Jun Lu, Jun Wang*, Arne Holmgren, Lili Zou*. Topical therapeutic efficacy of ebselen against multidrug-resistant Staphylococcus aureus LT-1 targeting thioredoxin reductase [J]. Frontiers in Microbiology. 2019, 10: 3019-303.
(9) Xiaoyuan Ren*, Lili Zou, Arne Holmgren*. Targeting bacterial antioxidant systems for antibiotics development [J]. Current Medicinal Chemistry. 2020, 27, 1-18.
(10) Huan Chen#, Lili Zou#, Chuanjiang Dong, Tao Li, Ziqiang Dong*. Advanced primary urethral cancer: a case report [J]. Journal of Medical Case Reports. 2019, 13: 365-371.
(11) Yu Gao#, Honglei Zhao#, Peng Wang, Jun Wang*, Lili Zou*. The role of SOCS3 and STAT3 in infection and inflammatory diseases [J]. Scandinavia Journal of Immunology. 2018, 88(6): 12727-12738.
(12) Lili Zou#, Jun Wang#, Yu Gao, Xiaoyuan Ren, Martin E. Rottenberg, Jun Lu*, Arne Holmgren*. Synergistic antibacterial activity of silver with antibiotics correlating with the upregulation of the ROS production [J]. Scientific Reports. 2018, 8: 11131-11141.
(13) Xiaoyuan Ren, Lili Zou, Jun Lu, Arne Holmgren*. Selenocysteine in mammalian thioredoxin reductase and application of ebselen as a therapeutic [J]. Free radical Biology and Medicine. 2018, S0891-5849(18): 30914-30916.
(14) Song Qin, Yu Liu, Jun Wang*, Lili Zou*. Silencing of suppressor of cytokine signaling 1 enhances the immunological effect of mucin 1-calreticulin-primed 4T1 cell-treated dendritic cells in breast cancer treatment [J]. Oncology Letter. 2018, 15(2): 1630-1638.
(15) Lili Zou, Jun Lu*, Jun Wang, Lanlan Zhang, Xiaoyuan Ren, Yu Gao, Martin E. Rottenberg, Arne Holmgren*. Synergistic antibacterial effect of silver and ebselen against multidrug-resistant Gram-negative bacterial infections [J]. EMBO Molecular Medicine. 2017, 9(8): 1165-1178.
(16) Xiaoyuan Ren#, Lili Zou#, Xu Zhang, Vasco Branco, Jun Wang, Cristina Carvalho, Arne Holmgren, Jun Lu*. Redox signaling mediated by the Thioredoxin system and glutathione systemin the central nervous system [J]. Antioxidant &Redox signaling. 2017, 27(13): 989-1010.
(17) Yang Liu#, Zhaoyu Qin#, Lili Cai, Lili Zou, Jing Zhao, Fan Zhong*. Selection of Internal References for qRT-PCR Assays of Human Hepatocellular Carcinoma Cell Lines [J]. Bioscience Reports. 2017, 37(6): BSR20171281-9.
(18) Jun Wang#, Zhipeng Gao#, Song Qin, Changbo Liu, Lili Zou*. Calreticulin is an effective “Immunologic Adjuvant” to tumor associate antigen [J]. Experimental and Therapeutic Medicine. 2017,14: 3399-3406.
(19) Chengliang Yang, Jun Wang*, Lili Zou*. Innate immune evasion strategies based Cryptococcal meningitis caused by Cryptococcus neoformans [J]. Experimental and Therapeutic Medicine. 2017, 14: 5243-5250.
(20) Chao Tan#, Jun Wang#, Peng Wang, Yifang Hu, Lili Zou*. Staphylococcus epidermidis Delta Sortase A strain elicits protective immunity against Staphylococcus aureus infection [J]. Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology. 2017, 110(1): 133-143.
(21) Hu Wang, Jielan Ma, Yinggui, Yang, Yang Song, Jiao Wu, Yanyan Qin, Xueli Zhao, Jun Wang, Lili Zou, Jiangfeng Wu, Junming Li, Changbai Liu. Efficient therapeutic delivery by a novel cell-permeant peptide derived from KDM4A for antitumor and antifibrosis [J]. Oncotarget. 2016, 7(31): 49075-49090.
(22) Xiaoyue Deng, Hu Wang, Tao Wang, Xiantao Fang, Lili Zou, Zhiying Li, Changbai Liu. Non-viral methods for generating integration-free, induced pluripotent stem cells [J]. Current Stem Cell Research & Therapy. 2015, 10(2):153-158.
(23) Chao Tan, Li Han*, Lili Zou, Chunhua Luo, Aihua Liu, Xiejing Sheng, Dee Xi. Expression of P2X7R in Breast Cancer Tissue and the Induction of Apoptosis by the Gene-specific shRNA in MCF-7 Cells [J]. Experimental and Therapeutic Medicine. 2015, 10(4): 1472-1478.
(24) Jun Wang, Lili Zou, Anxing Li. Construction of a Streptococcus iniae sortase A mutant and evaluation of its potential as an attenuated modified live vaccine in Nile tilapia (Oreochromis niloticus) [J]. Fish & Shellfish Immunology. 2014, 40: 392-398.
(25) Lili Zou, Jielan Ma, Tao Wang, Tangbin Yang, Changbai Liu*. Cell-Penetrating Peptides-Mediated Therapeutic Molecules Delivery to the Central Nervous System [J]. Current Neuropharmacology. 2013, 11, 197-208.
(26) Baofeng Huang#, Lili Zou#, Jun Xie, Zang Huang, Yi Li, An xing Li*. Immune responses of different species of tilapia infected with streptococcus agalactiae [J]. Journal of Fish Diseases. 2013, 36(8): 742-752.
(27) Jun Wang#, Lili Zou#, An xing Li*. A novel transporter in streptococcus iniae [J]. Journal of Fish Diseases. 2013, 36(12): 1007-1015.
(28) Lili Zou, Jun Wang, Baofeng Huang, MingquanXie, Anxing Li*. A Solute-binding Protein for Iron Transport in Streptococcus iniae [J]. BMC Microbiology. 2011, 10: 309-318.
5. Published Books (since 2011)
Jun Lu, Xiaoyuan Ren, Lili Zou, Arne Holmgren. Ebselen and thioredoxin systems in human health, disease and therapeutic potential. Jain VK, Priyadarsini I, Organoselenium compounds in biology and medicine. Chapter 11, 303-313. The royal society of chemistry, Cambridge. ISBN O-85186-375-2.
6. Research Projects (since 2011)
(1) National Natural Science Foundation of China (32170191), 2022. 1-2025. 12, Host
(2) National Natural Science Foundation of Hubei Province (2021CFB497), 2021. 9-2023. 10, Host
(3) National Natural Science Foundation of China (81903105), 2020. 1-2022. 12, Participate
(4) National Natural Science Foundation of China (81971248), 2020. 1-2023. 12, Participate
(5) The Health Commission of Yichang (A19-301-50), 2019. 1-2021. 12, Host
(6) The Health Commission of Hubei Province (WJ2019H528), 2019. 11-2022. 11, Participate
(7) Minister of Education of Hubei Province (B2016022), 2016. 1-2017. 12, Participate
(8) The Health Commission of Yichang (A26301-14), 2016. 1-2017. 12, Participate
(9) Minister of Education of Hubei Province (Q20151204), 2015. 1-2016. 12, Host
(10) National Natural Science Foundation of China (81201766), 2013. 1-2015. 12, Host
7. Honors and Awards(since 2011)
(1) 2021 China industry university research cooperation innovation and Promotion Award - second prize of industry university research guest innovation achievement award
(2) The second prize of the 2021 young teachers' teaching competition for clinical medicine (English teaching) of international students from Three Gorges University in China
(3) The second prize of natural science and technology achievements of Three Gorges University in 2018
(4) The second prize of natural science and technology achievements of Three Gorges University in 2017
8. Membership of Professional Bodies
(1) Chinese Society for Immunology
(2) Chinese Society for Microbiology
(3) Review editor in Frontiers in Antibiotics
Dr. Dun Yaoyan
E-mail: dyydxy2004@163.com
Faculty: Department of Pathology, Medical College of China Three Gorges University
Job Title: Associate Professor
1. Education
(1) September 2009-June 2012: Doctor's degree, Huazhong University of Science &
Technology
(2) September 2004-June 2007: Master's degree, China Three Gorges University
2. Professional Experiences
July 2012-now: Medical College of China Three Gorges University
3. Research Directions
(1) Pathogenesis of Intestinal Barrier
(2) Pathogenesis of Intestinal Stem Cells
4. Published Papers (since 2011)
(1) Yuhui Guo#, Zhihao Cheng#, Jie Liu, Yumin He, Zhengguo Xiong, Ding Yuan, Yaoyan Dun*, Changcheng Zhang*. Protective effects of saponins from Panax japonicus on neurons of the colon myenteric plexus in aging rats through reduction of α-synuclein through endoplasmic reticulum stress, Geriatr Gerontol Int. 2021, 21(1): 85-93.
(2) Yaoyan Dun#, Jing Chen#, Jie Liu, Yuhui Guo, Changcheng Zhang*, Ding Yuan*. Changes of Wnt/β-catenin signalling, BMP2, and BMP4 in the jejunum during ageing in rats, Arab J Gastroenterol. 2020, 21(1): 43-48.
(3) Yaoyan Dun#, Zhihao Cheng#, Jie Liu, Yuhui Guo, Yumin He, Zhengguo Xiong, Ding Yuan*, Changcheng Zhang*. Distinct expression patterns of aging effects on the UPRERsignaling pathway in rat colon and regulatory role of saponins from Panax japonicus, Int J Clin Exp Pathol. 2019, 12(9): 3279-3289.
(4) Yaoyan Dun#, Min Liu#, Jing Chen, Danli Peng, Haixia Zhao, Zhiyong Zhou, Ting Wang, Chaoqi Liu, Yuhui Guo, Ding Yuan*, Changcheng Zhang*. Regulatory effects of saponins from Panax japonicus on colonic epithelial tight junctions in aging rats, Journal of Ginseng Research. 2018, 42(1): 50-56.
5. Research Projects (since 2011)
(1) 2021, Effect of Total Saponins of Panax Japonicus on Intestinal Lipid Metabolism in Obese Mice and its Mechanism, the Traditional Chinese Medicine Project of Hubei Health Committee, ZY2021M105
(2) 2015, the Mechanism of Intestinal Mucosal Barrier Dysfunction in Aging Rats from AMPK Mediated Autophagy and the Regulatory Effect of Total Flavonoids of Epimedium, NSFC Youth Fund Project, 81503423.
