张家玉 博士,副教授，副主任医师，肿瘤科副主任。2000年毕业于华中科技大学同济医学院临床医学专业，获医学学士，留病理生理学系任教，开始参加AD病发病中tau蛋白作用机制研究。2004年6月获病理生理学系硕士学位。2008年6月获病理生理学系博士学位。2009年2月至2012年12月份美国肯塔基老员工化系博士后，研究FUS/TLS在肌萎缩侧索硬化症（ALS）中的作用。2013年1月开始工作于bat365中文官方网站第一临床医学院肿瘤科。2019年5-7月英国诺丁汉大学城市医院肿瘤中心访问学者。2019年8月-2020年1月复旦大学肿瘤医院进修学习。目前研究方向为自噬在乳腺癌发生及转移中的作用及机制，乳腺癌、肺癌等恶性肿瘤临床指标与预后的关系。
主持完成的科研课题：
1，国家自然科学青年基金，2006年，细胞内磷酸化tau蛋白降解途径的研究
2，国家自然科学基金面上项目，2010年，自噬障碍在tau异常聚积中的作用以及相关机制与干预研究
3，国家自然科学基金面上项目，2013年，下调磷酸酯酶2A抑制因子降低Abeta的机制及其神经保护作用的研究。
代表性论文：
Arenas A, Kuang L,Zhang J, Kingren MS, Zhu H. FUS regulates autophagy by mediating the transcription of genes critical to the autophagosome formation. J Neurochem. 2020 Dec 22. doi: 10.1111/jnc.15281. Epub ahead of print.
Kapeli K, Pratt GA, Vu AQ, Hutt KR, Martinez FJ, Sundararaman B, Batra R, Freese P, Lambert NJ, Huelga SC, Chun SJ, Liang TY, Chang J, Donohue JP, Shiue L,Zhang J, Zhu H, Cambi F, Kasarskis E, Hoon S, Ares M Jr, Burge CB, Ravits J, Rigo F, Yeo GW. Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses. Nat Commun. 2016 Jul 5;7:12143
Shang XL, Wang QB, Liu XP, Yao XQ, Cao FY, Wang Q,Zhang JY, Wang JZ, Liu GP (co-corresponding author). Fluorocitrate induced the alterations of memory-related proteins and tau hyperphosphorylation in SD rats. Neurosci Lett. 2015 Jan 1;584:230-5.
Yang L,Zhang J, Kamelgarn M, Niu C, Gal J, Gong W, Zhu H. Subcellular localization and RNAs determine FUS architecture in different cellular compartments. Hum Mol Genet. 2015; 24(18):5174-83
Zhang Y, Ma RH, Li XC,Zhang JY, Shi HR, Wei W, Luo DJ, Wang Q, Wang JZ, Liu GP. Silencing I2PP2A Rescues Tau Pathologies and Memory Deficits through Rescuing PP2A and Inhibiting GSK-3β Signaling in Human Tau Transgenic Mice. Front Aging Neurosci. 2014; 6:123
Convertini P,Zhang J(co-first author), de la Grange P, Hayward LJ, Zhu H, Stamm S. Genome wide array analysis indicates that an amyotrophic lateral sclerosis mutation of FUS causes an early increase of CAMK2N2 in vitro. Biochim Biophys Acta. 2013 Aug;1832(8):1129-35
Dhar SK,Zhang J, Gal J, Xu Y, Miao L, Lynn BC, Zhu H, Kasarskis EJ, St Clair DK. FUsed in Sarcoma Is a Novel Regulator of Manganese Superoxide Dismutase Gene ranscription. Antioxid Redox Signal. 2014 Apr 20;20(10):1550-66.
Niu G,Zhang J(co-first author), Gao F, Yang L, Jia M, Zhu H and Gong W. FUS-NLS/Transportin 1 complex structure provides insights into the nuclear targeting mechanism of FUS and the implications in ALS. PLOS ONE 2012;7(10):e47056
Gal J,Zhang J, Kwinter DM, Zhai J, Jia H, Jia J, Zhu H. Nuclear localization sequence of FUS and induction of stress granules by ALS mutants. Neurobiol Aging. 2011; 32(12): 2323.e27-40.
Gal J, Ström AL, Kwinter DM, Kilty R,Zhang J, Shi P, Fu W, Wooten MW, Zhu H. Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin- independent mechanism. J Neurochem. 2009;111(4):1062-73.
Zhang JY, Peng CX, Wang Q, Wang JZ. Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain. J Alzheimer Dis. 2008; 15:1-9
Liu SJ,Zhang JY(co-first author), Li HL, Fang ZY, Wang Q, Deng HM, Gong CX, Grundke-Iqbal I, Iqbal K, Wang JZ. Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain. J Biol Chem. 2004; 279(48):50078-88 (co-first author)
Zhang JY, Liu SJ, Li HL, Wang JZ. Microtubule-associated protein tau is a substrate of ATP/Mg2+-dependent proteasome protease system. J Neural Transm. 2005; 112(4): 547-55.
