主要研究领域为血液原虫巴贝斯虫药物靶标鉴定、药物筛选与设计，并取得了一定的创新性成果。获授权国内发明专利5项，以第一作者发表SCI论文4篇，共同作者SCI论文20余篇，其中包括FASEB journal, Frontiers in Pharmacology, Frontiers in Immunology等知名杂志；主持国家自然科学基金青年项目1项，博士后基金1项，中国疾病预防控制中心开放基金、横向课题各1项，参与国家自然科学基金面上项目1项。以项目骨干参与“十四五”国家重点研发计划2项。
主要研究方向：
（1）蜱传病毒宏基因组测序及新发蜱传疾病鉴定；
（2）抗巴贝斯虫药物靶标鉴定及药物筛选；
（3）利用结构生物学与蛋白质互作探究巴贝斯虫分裂周期调控及抗氧化能力等。
招生方向：基础医学（学术型）；联系方式：yulong@ctgu.edu.cn
近几年发表SCI文章收录情况：
Yu L,Liu Q,Luo W, Zhao J,AlzanH,He L*.The Structural Basis ofBabesia orientalisLactate Dehydrogenase.Front. Cell. Infect. Microbiol.2021 Dec;doi: 10.3389/fcimb.2021.790101.
Yu L,Zhan X, Liu Q, Sun Y, Li M, Zhao Y, An X, Tian Y, He L* , Zhao J. Identifying the Naphthalene-based Compound 3, 5-Dihydroxy 2-Napthoic Acid (DHNA) as a Novel Lead Compound for Designing LDH-specific Antibabesial Drug.Front Pharmacol.2020Jan30;doi: 10.3389/fphar.2019.01663.
Yu L,Shen Z, Liu Q, Zhan X, Luo X, An X, Sun Y, Li M, Wang S, Nie Z, Ao Y, Zhao Y, Peng G, Mamoun CB, He L*, Zhao J. Crystal structures ofBabesia microtilactate dehydrogenase BmLDH reveal a critical role for Arg99 in catalysis.FASEB J.2019Dec25; doi: 10.1096/fj.201901259R.
Yu L,Liu Q, Zhan X, Huang Y, Sun Y, Nie Z, Zhao Y, An X, Li M, Wang S, Ao Y, Huang C He L, Zhao J*. Identification and molecular characterization of a novelBabesia orientalisthrombospondin-related anonymous protein (BoTRAP1).Parasit Vectors.2018 Dec 27;doi: 10.1186/s13071-018-3245-2.
Lan He; Reginaldo G. Bastos;Long Yu; Jacob M. Laughery; Carlos E. Suarez ; Lactate Dehydrogenase as a Potential Therapeutic Drug Target to ControlBabesia bigemina,Front. Cell. Infect. Microbiol, 2022: 12-87085.
Zhan X,Yu L, An X, Liu Q, Li M, Nie Z, Zhao Y, Wang S, Ao Y, Tian Y, He L*, Zhao J*. Evaluation ofBabesia gibsoniGPI-anchored Protein 47 (BgGPI47-WH) as a Potential Diagnostic Antigen by Enzyme-Linked Immunosorbent Assay.Front Vet Sci. 2019; 6:333.
Zhan X, HeJ,YuL, LiuQ, SunY, NieZ, GuoJ, ZhaoY, LiM, LuoX, He L*, and ZhaoJ.Identification of a novel thrombospondin-related anonymous protein (BoTRAP2) fromBabesia orientalis.Parasit Vectors. 2019; 12 (1):200.
Sun Y, He L*,Yu L, Guo J, Nie Z, Liu Q, Zhao J*. Cathepsin L—a novel cysteine protease fromHaemaphysalis flava Neumann, 1897.Parasitol. Res. 2019, 118 (5): 1581-1592.
Sun Y, Liu Q, Zhang Y, He L,Yu L, Zhao J*. Prevalence of piroplasma in ticks collected from dogs and cattle in Guangxi, South China determined by reverse line blot hybridization assay.J. Parasitol.2019, 105 (4): 651-658.
Cui J, Zhao Y, Sun Y,Yu L, Liu Q, Zhan X, Li M, He L*, Zhao J. Detection ofBabesia gibsoniin dogs by combining recombinase polymerase amplification (RPA) with lateral flow (LF) dipstick.Parasitol. Res.2018;117(12):3945-3951.
He L, He P, Luo X, Li M,Yu L, Guo J, Zhan X, Zhu G, Zhao J*. The MEP pathway inBabesia orientalisapicoplast, a potential target for anti-babesiosis drug development.Parasit Vectors. 2018; 11:452.
MalobiN, He L*,Yu L, He P, He J, Sun Y, Huang Y, Zhao J*. Molecular cloning and characterization ofBabesia orientalisRhoptry Neck 2 BoRON2 protein.J. Parasitol. Res. 2017; 2017:7259630.
He L, Miao X, Hu J, Huang Y, He P, He J,Yu L, Malobi N, Shi L, Zhao J*. First molecular detection ofBabesia gibsoniin dogs from Wuhan, China.Front Microbiol. 2017;8:1577.
Huang Y, He L*, Hu J, He P, He J,Yu L, Malobi N, Zhou Y, Shen B, Zhao J*. Characterization and annotation ofBabesia orientalisapicoplast genome.Parasit Vectors. 2015; 8:543.
He L, Fan L, Liu Q, Hu J, Miao X, Huang Y, He P, He J,Yu L, Muhammad K, Zhou Y, Shen B, Zhao J*. Identification and characterization of a novel 34 kDa merozoite protein inBabesia orientalis.Vet. Parasitol. 2015; 212 (3-4):411-6.
已授权专利5项：
贺兰;赵阳楠;赵俊龙;崔杰;喻龙;聂政;战雪燕;申邦;胡敏;周艳琴;方瑞;一种东方巴贝斯虫RPA分子检测方法, 2022-02-08,中国,ZL 2018 1 1346598.4
贺兰;赵俊龙;喻龙;战雪燕;刘琴;赵阳楠;周艳琴;方瑞;申邦;胡敏;一种抗田鼠巴贝斯虫的单克隆抗体及其应用, 2021-05-18,中国, ZL 2018 1 0045325.X
贺兰;敖阳思琦;战雪燕;喻龙;聂政;崔杰;刘琴;赵俊龙;一种犬吉氏巴贝斯虫表面蛋白及其应用,2020-12-18,中国, ZL 2019 1 0439971.9
贺兰;赵俊龙;何沛;周艳琴;方瑞;申邦;胡敏;喻龙;东方巴贝斯虫1-脱氧-D-木酮糖-5-磷酸还原异构酶基因及其编码的蛋白, 2019-10-18,中国,ZL 2017 1 0086334.9
贺兰;赵俊龙;喻龙;何军伟;何沛;黄源;东方巴贝斯虫凝血酶素基因1及其编码的蛋白, 2018-11-06,中国,ZL 2016 1 0008132.8
