(导师： 沈岩教授)
● 2006.09~2010.06 华中科技大学同济医学院， 学士
主持项目
● ELANE 基因终末外显子移码突变导致重症先天性粒细胞减少症的分子机制研究 天津市自然科学基 金， 2022.07~2024.12， 6 万 (主持)
● 体内造血干细胞基因编辑及其基因治疗 细胞生态海河实验室揭榜挂帅项目， 2022.01~2024.12， 150 万(主持)
● 血液病的细胞与基因治疗机制、新策略及临床应用 中国医学科公司医学与健康科技创新工程项目，
360 万(子课题负责人)
● 分子伴侣介导的自噬与造血干细胞衰老 国家重点研发计划青年科学家项目， 165 万 (子课题负责人)
● 中性粒细胞发育和自发性死亡机制 中国医学科学院引进人才项目， 500 万(主持)
课题组简介及研究方向
本课题组长期致力于血液系统疾病的功能基因组和基因治疗研究， 近 5 年来以第一作者和(或) 通讯 作者(含共同) 在 Cell Stem Cell、Genome Medicine、Journal of Clinical Investigation、American Journal of Human Genetics 、Signal Transduction and Targeted Therapy 和 Nature Communications 等期刊发表论文 20 余篇； 并以合作者身份在 Nature Genetics 、Neuron 等期刊上发表论文数篇。论文被包括 Nature、 Science 、Cell 和 New England Journal of Medicine 等在内的期刊引用 1000 余次。
研究方向为： 1) 基因编辑工具研发； 2) 高通量功能筛选； 3) 遗传性疾病基因治疗。
近 5 年代表性论文(#第一作者， *通讯作者)
1. Shuquan Rao#, Yao Yao#,Josias Soares de Brito#, Qiuming Yao,Anne H Shen,Ruth E Watkinson,Alyssa L Kennedy,Steven Coyne,Chunyan Ren,Jing Zeng,Anna Victoria Serbin,Sabine
Studer, Kaitlyn Ballotti,Chad E Harris, Kevin Luk,Christian S Stevens, Myriam Armant, Luca Pinello,Scot A Wolfe, Roberto Chiarle,Akiko Shimamura,Benhur Lee, Peter E Newburger,Daniel E Bauer*. ELANE neutropenia pathogenicity dissected by human hematopoietic stem cell gene editing. Cell Stem Cell, 2021, 28:1-13 (Featured article). (IF=25.27)
This work was selected as plenary talk by both 62nd American Society of Hematology (ASH) Annual
Meeting and 70th American Society of Human Genetics (ASHG) Annual Meeting.
2. Fuquan Zhang#*,Shuquan Rao#, Hongbao Cao, Xiangrong Zhang,Qiang Wang,Yong Xu,Jing Sun,Chun Wang,Jiu Chen, Xijia Xu,Ning Zhang,Lin Tian, Jianmin Yuan, Guoqiang Wang,Lei Cai, Mingqing Xu#,Ancha Baranova#. Genetic evidence suggests posttraumatic stress disorder as a subtype of major depressive disorder. Genetic evidence suggests posttraumatic stress disorder as a
subtype of major depressive disorder. J Clin Invest, 2022 Feb 1;132(3):e145942. (IF=19.46)
3. Shuquan Rao#,Ancha Baranova#,Hongbao Cao,Jiu Chen, Xiangrong Zhang,Fuquan Zhang*. Genetic mechanisms of COVID- 19 and its association with smoking and alcohol consumption. Brief Bioinform, 2021 Nov 5;22(6):bbab284. (IF=13.99)
4. Shuquan Rao#*, Yao Yao#, Daniel E Bauer*. Editing GWAS: experimental approaches to dissect and exploit disease-associated genetic variation. Genome Med, 2021 Mar 10;13(1):41. (IF=15.27)
5. Yao Hu#, Adrienne M. Stilp#, Caitlin P. McHugh#, Shuquan Rao# … …, Guillaume Lettre, Nathan Pankratz, Cecelia A. Laurie, Cathy C. Laurie, Alexander P. Reiner*, the NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. Whole genome sequencing association analysis of quantitative red blood cell phenotypes: the NHLBI TOPMed program. Am J Hum Genet, 2021 Jun 3;108(6):1165. (IF=11.04)
6. Yao Yao#, Fei Ye#, KaiLong Li#, Peng Xu, WenJie Tan, Quansheng Feng*, Shuquan Rao#*. Genome editing identified CCR9 and SLC6A20 as potential target genes at the 3p21.31 severe COVID- 19 locus. Signal Transduct Target Ther 2021, 6:85. (IF=38.10)
7. Zhihua Yang, Shuang Zhang, Fuquan Zhang, Yao Yao, Kwangwoo Kim, David Meyre, Hongmei Zhang, Hai Liao, Shuquan Rao*, Xinhe Huang*. Allelic frequency differences of DAOA variants between Caucasians and Asians and their association with major mood disorders. Signal Transduct Target Ther, 2019, 4: 39. (IF=38.10)
8. Yao Yao#, Jia Yang#, Yimin Xie, Hai Liao, Baoying Yang, Qi Xu, Shuquan Rao#*. No Evidence for Widespread Positive Selection Signatures in Common Risk Alleles Associated with Schizophrenia. Schizophr Bull, 2020, 46 (3): 603-611. (IF=9.31)
9. Shuquan Rao#*, Na Luo#, Jing Sui, Qi Xu, Fuquan Zhang*. Effect of the SIRT1 gene on regional cortical grey matter density in the Han Chinese population. Br J Psychiatry, 2020, 216 (5): 254-258.
(IF=10.67)
10. Yao Yao,Jia Yang,Qian Qin,Chao Tang, Zhidan Li,Li Chen, Kailong Li, Chunyan Ren,Lu Chen*,Shuquan Rao*. Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation. Commun Biol, 2020,
3(1): 790. (IF=6.55)
11. Sha Liu#,Shuquan Rao#,Yong Xu#,JunLi#,Hailiang Huang,Xu Zhang,Hui Fu, Qiang Wang,Hongbao Cao, Ancha Baranova, Chunhui Jin,Fuquan Zhang*. Identifying common genome-wide risk genes for major psychiatric traits. Hum Genet, 2020, 139(2): 185- 198. (IF=5.88)
学术报告
1. 70th 美国人类遗传学大会 (2020/10/27~2020/10/30) 特邀英文报告
